Home/ Glossary/ International Health Regulations (IHR) International Health Regulations (IHR) The legally-binding WHO framework for cross-border public-health events. IHR notification triggers cross-border data sharing, contact tracing co-ordination, and (rarely) declaration of a Public Health Emergency of International Concern (PHEIC). Related glossary terms Hantavirus A genus of rodent-borne RNA viruses that cause severe diseas… Hantavirus pulmonary syndrome (HPS) A severe, often fatal lung disease caused by New World hanta… Hemorrhagic fever with renal syndrome (HFRS) A severe kidney-and-bleeding disease caused by Old World han… Case-fatality ratio (CFR) The proportion of confirmed cases of a disease that result i… Reservoir host A species in which a pathogen circulates persistently and as…